Using drug-excipient interactions for siRNA delivery
نویسندگان
چکیده
منابع مشابه
General Considerations Modes of Drug Decomposition Drug–excipient Interactions
Excipients are included in dosage forms to aid manufacture, administration or absorption. Other reasons for inclusion concern product differentiation, appearance enhancement or retention of quality.1 They rarely, if ever, possess pharmacological activity and are accordingly loosely categorized as ‘inert.’ However, excipients can initiate, propagate or participate in chemical or physical interac...
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Ketoprofen (3-benzoyl-alpha-methylbenzeneacetic acid) is a widely used nonsteroidal anti-inflammatory drug (NSAID), always administered in the form of drug-excipient physical mixtures (PMs). The occurrence of possible interactions between ketoprofen and two commonly used excipients-lactose (LAC) and polyvinylpyrrolidone (PVP)-was evaluated, through vibrational spectroscopy techniques [both Rama...
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Since the discovery of the "starburst polymer", later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups. In recent years, dendrimers have been studied extensively...
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Background Because of its rarity, drug excipients allergy is often unsuspected by the doctors. Some times the active drug is blamed and discontinued unnecessarily when the real culprit is drug excipients. This was suspected when patients reported exacerbation of urticaria with anti histaminic which are actually used for treating urticaria. After suspecting drug excipient as the cause of allergy.
متن کاملDrug-Excipient Interactions: Case Studies and Overview of Drug Degradation Pathways
The objective of the current research article is to provide a comprehensive review of excipients impact on the stability of the drug product and their implications during the product development. Recent developments in the understanding of the degradation pathways further impact methodologies used in the pharmaceutical industry for potential stability assessment. The formation of drug excipient...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2011
ISSN: 0169-409X
DOI: 10.1016/j.addr.2011.09.003